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These two types of vascular changes (arterial remodeling and capillary rarefaction) negatively affect clinical outcome (FEV1, DLCO, etc.) by increasing pulmonary vascular resistance or decreasing gas diffusion capacity, respectively (56, 57)

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On 11 January 2014, it will be 50 years since the US surgeon general told the world that: "cigarette smoking contributes substantially to mortality from certain specific diseases and to the overall death rate." Since that warning first reverberated around the world, tobacco use has dropped staggeringly in developed countries

Food and Drug Administration (FDA) asked Dustin Poppendieck and his colleagues at the National Institute of Standards and Technology in Gaithersburg, Maryland, to put together a research study

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